Anti-Inflammatory and Anti-Nociceptive Properties of Aqueous Leaves Extract of Ipomoea Batatas (lam). On Experimental Animals

Abstract

Ipomoea batatas is sub-tropical and tropical region plant being
implicated in the treatment of several diseases as reported
ethnomedicinally. Leaves aqueous extract of I. batatas was evaluated for
the potential of anti-inflammatory and anti-nociceptive properties of
Wistar rats and mice. These autonomous studies, involving two phases
of the study of which twenty-five rats and mice were randomly divided
into groups of five (n=5). The studies involved formalin induced antiinflammatory effect in rats exhibiting edema on left hind sub-planter
paw. Acetic acid and hot plate induced pain in mice were evaluated via
peripheral and central acting anti-nociceptive property of Ipomoea
batatas plant extract. The extract was orally given across the treated
groups at graded doses: 50, 100 and 200 mg/kg with aspirin and
pentazocin as reference drug control whereas untreated control was
given water. The results gotten showed a significant reduction (p<0.05)
in the paw volume of the plant extract with anti-inflammatory property
was observed at 120, 180 and 240 minutes. From the anti-nociceptive
activity, a significant inhibitory effect (p<0.05) across the treated groups
with formalin and hot plate induced pain in mice. This research study
hence authenticates the folklore benefits of I. batatas leaves in treating
inflammation and nociceptives.