Experimentation of the Effects of Ethanol Extract of Emilia Coccinea on Induced Gastric Ulcer in Rats

Abstract

This paper presents the antiulcer activities of the ethanol extract of Emilia Coccinea leaves on indomethacin and ethanol –induced gastric ulcers were evaluated. Twenty Adult Whister rats of either sex were divided to five groups (5 rats/group). The results obtained show that the ulceration in gastric linings of the stomach of rats pre-treated with  Emilia Coccinea leaves extract before induction with ethanol and indomethacin decreased significantly when compared to the control. The preventive effect of the extract increased in a dose-dependent  manner in both ulcer models. We observed a significant decreases (p< 0.05) in the number of ulcer lesions when rats were administered with graded doses of the extract and ranitidine (100mg/kg body weights) compared with the control groups in both models. The results from the study reveals that the extract of Emilia Coccinea leaves has potential efficacy of protecting the stomach, linings against ulceration induced by both indomethacin and ethanol in rats.