Synthesis, Ft-Ir Characterization and Anti-Bacterial Activity of 5-Bromo-8- Quinolinoxyacetic Acid

Abstract

This paper involves the synthesis, FT-IR characterization and antibacterial activity of 5-bromo-8-quinolinoxylacetic acid. The synthesized
compound was prepared by bromination of 8-hydroxyquinoline with the
addition of bromine to give a mono brominated compound, 5-bromo-8-
hydroxyquinoline and coupling the 5-bromo-8-hydroxylquinoline
compound with chloro-acetic acid in the presence of NaOH, 5-bromo-8-
quinolinolinoxylacetic acid was produced. The compound was analyzed
by infra-red spectroscopy while anti-bacterial activity was done by
standard method. The synthesized compound had a milky green color,
with a solid state and powdery in nature, with a melting point of 206oC.
The anti-bacterial activity gave zones of inhibition of 9 mm
(Actinobacter), 29 mm (Staphylococcus aureus) at doses less than100
mg/ml showed a lesser zone of inhibition which suggest a dose dependent
activity. The IR bands were observed at 1049.31cm-1
(C-O stretch) for
carbonyl group; 1797.72cm-1
(C=O stretch) for acid halide, 794.7cm-1
(CH) bend for 1, 3 –disubstituted benzenes among others. Thus, the IR
results confirm the presences of functional groups present in the
synthesized compound. The compound showed a promising activity as
anti- bacterial agent.