Assessment of Modified Azadirachta Indica Leave Extract on Some Biochemical Indicators in Rats

Abstract

Azadirachta indicais a popular tropical plant with medicinal properties
used for the treatment of various infections.Thirtyfive young animals
were used in a 5 x 5 experimental design and were grouped according to
weight proximity and labeledas Control,Test A (0.25), Test B (0.50),
Test C (0.75) and Test D. (1.0). Data collected were subjected to one way
ANOVA using Graph pad Prism 6.0. Serum and liver tissues were
assayed for glucose, cholesterol, total protein, alanine aminotransferase
(ALT), aspartate aminotransferase (AST) and gamma glutamyl
transferase (GGT), superoxide dismutase (SOD), catalase and
malondialdehyde (MDA) using standard protocols. There were
significant (p<0.05) reductions in serum MDA, and cholesterol with a
significant (p<0.05) increase in liver total protein in comparison with
control. All other parameters were not significantly altered in comparison
with control.The impact of this result is that the aspartame modified
Azadirachta indicaleave extracts could further enhance the lipid
peroxidation potential of the extracts and also protect against cholesterol
linked maladies.