Synergistic Effects of Synclistia Scarbrida and Sterculia Tragacantha on Pregnancy Development and Blood Parameter of Gravid Dams

Abstract

The evaluation of synergistic effect of aqueous extract Synclistia scarbrida and Sterculia  tragacantha (AESSST) on some Dams and pups  parameter of matured pregnant wistar rats was carried out .8 groups of   rats (5 each) received the extracts, at two oral doses of 0, 50, and 300 mg /kg/ day, administered orally for a period of 0-21 days and 14- 21  all the Dams undergoing the treatment received single dose of oxytocin at day 12 of the experiment .The  Dams and pups, were evaluated for letter size inutero , Hematological indices was improved whit blood cell Wbc when compared with the control 15.4±0.0 , 16.42±0.2^a,  and 18.21±1.0^d , for  Red blood cell  Rbc the improvement was observed  to have significantly increased  when compared to the control 5.8±0, 6.6±0.1^a, and 8.4±0.1^d,The pac cell volume Pcv was found significantly increased when compared to the control with p-values at 34.6±0.4 , 35.45±0.1^b and 38.96±0.4^d. Platelet   Plt and Neu were parameters maintained unaffected when compared with the control 67.01±0.2, 66.90±0.2 and 66.89±0.7 Plt and Neutrophil Neu 20.98±0.3, 21.00±0.2 and 20.99±0.3.The Body Weight Index of the gravid dams was seen presenting significant increases  when compared to the control at day 7 183.9±0.2, 192.1±3.9^b and 204.2±5.2^d with values at  mean while significant increases was indicated with p-values at a = p< (0.05), b =p< (0.01),c =  p< (0.001) and d = p< (0.0001).Assessment of gravid rats were done using standard procedures such as examination Number of uterine implant, calculation of percentage % of Quantal pregnancy, calculation of percentage Implantation index, calculation of Pre-implantation loss if any ,percentage calculation of Gestation Index finally calculation of Mean gestation day calculated in days .The extract was concluded to have acted as an  immune boosting agents and fertility enhancer on the basis of reported result of the hematological assay, as  it was revealed that there was significant increases in the number of red and white blood cells, Pac cell volume, with  platelet and Neutrophil maintained unaffected . Conclusively, AESSST favored pregnancy developmental parameters, increased litter sizes, prevented miscarriages, and acted as a natural immune-boosting agent, thereby supporting its folkloric and synergistic uses during pregnancy.